5-MeO-DMT or O-methyl-bufotenin, is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and also is secreted by the glands of at least one toad species, the Sonoran Desert toad. Like its close relatives DMT and bufotenin, it has been used as an entheogen in South America.
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5-MeO-DMT is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine).
Like the other tryptamines, 5-MeO-DMT has the same basic structure as DMT, but has a methoxy group in the R5 position. It works primarily as a serotonin (5-HT) receptor agonist, with a particular binding affinity to the 5-HT1A receptor subtype. It also binds to 5-HT2A and trace amine receptors, possibly mediating hallucinogenic effects via the latter.
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Harm Reduction Tips
WHEN USING DMT KEEP IN MIND:
Start low and go slow. You cannot judge content or purity by appearance, and DMT amounts can vary within each batch
DMT causes vivid hallucinations so it is extremely important to have a sober “sitter” present who you know and trust and use in a safe and relaxing environment
Individuals with a personal or family history of any psychotic disorder or nonpsychotic mania should avoid taking any psychedelic compounds, including DMT.
Do not combine DMT with Lithium or SSRIs
5-MeO-DMT has seen a meteoric rise in popularity over the past few years as anecdotal reports of its potential as a healing agent have come to light. This has incentivized some bad practices among guides and other practictioners, including everything from overharvesting and the ecological strain on Sonoran Desert toad mentioned above, as well as sexual abuse and even unintended deaths in several documented cases.