Dimethyltryptamine ( DMT )

Dimethyltryptamine ( DMT )

 

Dimethyltryptamine ( DMT ), N, N-Dimethyltryptamine is a substituted tryptamine that occurs in many plants and animals and which is both a derivative and a structural analog of tryptamine. It is used as a recreational psychedelic drug and prepared by various cultures for ritual purposes as an entheogen. 

 

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DMT is a white crystalline powder that is derived from certain plants found in Mexico, South America, and parts of Asia, such as Psychotria viridis and Banisteriopsis caapi.

Various ways of consumption:

• vaporized or smoked in a pipe
• consumed orally in brews like ayahuasca
• snorted or injected on rare occasions

The chemical root structure of DMT is similar to the anti-migraine drug sumatriptan, and it acts as a non-selective agonist at most or all of the serotonin receptors, particularly at the serotonin 5-ht2a receptor. Serotonin is a neurotransmitter that has a large effect on the majority of our brain cells.

 

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DMT is generally not active orally unless it is combined with a monoamine oxidase inhibitor (MAOI), such as harmaline. Without an MAOI, the body quickly metabolizes orally-administered DMT, and it therefore has no hallucinogenic effect unless the dose exceeds monoamine oxidase’s metabolic capacity (very rare). Other means of ingestion such as smoking or injecting the drug can produce powerful hallucinations and entheogenic activity for a short time (usually less than half an hour), as the DMT reaches the brain before it can be metabolised by the body’s natural monoamine oxidase. Taking a MAOI prior to smoking or injecting DMT will greatly prolong and potentiate the effects of DMT.

 

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By the mid-20th century, ayahuasca had also been adopted as a sacrament by several urban sects in Brazil. The largest of these is the Uniao Do Vegetal, which combines elements of Christianity with indigenous Indian beliefs. UDV members also claimed that ayahuasca had helped them overcome alcoholism, drug addiction and other self-destructive behaviors. A decade ago, a branch of the UDV based in New Mexico sued for the right to consume ayahuasca legally in the U.S. In 2006 the U.S. Supreme Court ruled in favor of the group.

 

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How DMT Works

Like other psychedelic drugs, including shrooms and LSD, DMT acts on the serotonin receptors in the brain. The changes to serotonin levels and processing in the brain cause visual distortions, or hallucinations. The brain begins to interpret visual, and sometimes auditory, input differently. Most people who experience these changes report seeing an elven or mechanical, crystalline world. While the duration of the hallucination is usually short, the person who experiences it will usually feel that it was real. Some people who abuse the drug numerous times self-report that they have seen the underlying structure of the universe.

 

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